Hypoxia inhibits human recombinant large conductance, Ca 2+ ‐activated K + (maxi‐K) channels by a mechanism which is membrane delimited and Ca 2+ sensitive
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Voltage and Ca 2 1 Activation of Single Large - Conductance Ca 2 1 - activated K 1 Channels Described by a Two - Tiered Allosteric Gating Mechanism ✪
The voltageand Ca 2 1 -dependent gating mechanism of large-conductance Ca 2 1 -activated K 1 (BK) channels from cultured rat skeletal muscle was studied using single-channel analysis. Channel open probability ( P o ) increased with depolarization, as determined by limiting slope measurements (11 mV per e-fold change in P o ; effective gating charge, q eff , of 2.3 6 0.6 e o ). Estimates of q ef...
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Hypoxic inhibition of large-conductance Ca-dependent K channels (maxiK) of rat carotid body type I cells is a well-established fact. However, the molecular mechanisms of such inhibition and the role of these channels in the process of hypoxic transduction remain unclear. We have examined the mechanisms of interaction of O2 with maxiK channels exploring the effect of hypoxia on maxiK currents re...
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Hypoxic inhibition of large-conductance Ca(2+)-dependent K(+) channels (maxiK) of rat carotid body type I cells is a well-established fact. However, the molecular mechanisms of such inhibition and the role of these channels in the process of hypoxic transduction remain unclear. We have examined the mechanisms of interaction of O(2) with maxiK channels exploring the effect of hypoxia on maxiK cu...
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4 Raffaella Tonini, Teresa Ferraro, Marisol Sampedro-Castañeda, Anna Cavaccini, Martin 5 Stocker, Christopher D. Richards and Paola Pedarzani* 6 7 Research Department of Neuroscience, Physiology and Pharmacology, University College London, 8 London, UK. 9 Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy. 10 11 *To whom correspondence should be ad...
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Using the patch-clamp technique, we have identified two types of Ca(2+)-activated K+ (K(Ca)) channels in the human leukemic T cell line. Jurkat. Substances that elevate the intracellular Ca2+ concentration ([Ca2+]i), such as ionomycin or the mitogenic lectin phytohemagglutinin (PHA), as well as whole-cell dialysis with pipette solutions containing elevated [Ca2+]i, activate a voltage-independen...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2002
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jphysiol.2001.013888